NutriGrade Scoring System

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Study Title


Outcome


Intervention


1. Risk of bias/ study quality/ study limitations


No quantitative and descriptive information available
Risk of bias
Sequence generation
Allocation concealment
Blinding of participants and personnel
Blinding of outcome assessment personnel
Incomplete outcome
Selective reporting

Study quality

2. Precision


< 400 participants OR 400-2000 participants, but 95% CI overlaps the null value
> 2000 participants OR 400-2000 participants, but 95% CI excludes the null value

3. Heterogeneity


≤ 5 studies (0 P)
6-9 studies ≥ 10 studies
I2 (H2 and/or tau2)
I2 < 40%
I2 ≥ 40% Modelling detected heterogeneity with random effects model
None of the above
Exploring detected heterogeneity with subgroup analysis or meta-regression
Sensitivity analyses with higher levels of heterogeneity
95%CIs for I2

4. Directness


surrogate markers; differences in population; differences in intervention; network meta-analysis
hard clinical outcome; no important differences in population or intervention

5. Publication bias


< 5 studies OR evidence for severe bias with test or plot OR publication bias not assessed / reported
No evidence for publication bias with test or plot (5-9 studies) OR evidence for moderate / small amount of publication bias with test or plot
No evidence for publication bias with test or plot (≥10 studies)

6. Funding bias


Industry funding OR conflict of interest
Private institutions, foundations, non-governmental organizations
Academic institutions, research institutions

7. Study design




Total Score:





Grading scoring system meta-evidence:
Nutrigrade-Score Meta-evidence Explanation
≥ 8 points High There is high confidence for the effect estimate, and further research probably will not change the confidence in the effect estimate.
6 to 7.99 points Moderate There is moderate confidence for the effect estimate, further research could add evidence on the confidence and may change the effect estimate.
4 to 5.99 points Low There is low confidence for the effect estimate, further research will provide important evidence on the confidence and likely change the effect estimate.
0 to 3.99 points Very low There is very low confidence for the effect estimate; meta-evidence is very limited and uncertain.